高宏帅

一、个人简介

高宏帅，女，1995年生，讲师，研究方向为农业昆虫与害虫防治。目前主要致力于研究寄生蜂与鳞翅目寄主的互作机制，并以此为基础开展鳞翅目害虫的生物防治研究。

二、   教育背景

2018/09-2023/06，浙江大学，农业昆虫与害虫防治专业，博士（直博）

2014/09-2018/06，西北农林科技大学，植物保护专业，学士

三、   成果介绍

关键成果：

参加国家重点研发计划课题（2024YFD1400902,双季稻区二化螟灾变主导因子、暴发机制与可持续防控技术研究，2025/05-2028/04）。

以第一作者发表的论文：

Gao HS, Guo MJ, Yang X, Hu RM, Wu K, Pang L, Ye XQ, Huang JH, Chen XX, Wang ZZ. Parasitic castration by a viral protein tyrosine phosphatase targeting the host cell cycle checkpoint protein Rad9A. Proc Natl Acad Sci U S A. 2026 Feb 17;123(7):e2524949123. doi: 10.1073/pnas.2524949123.

Gao HS, Hu RM, Wang ZH, Ye XQ, Wu XT, Huang JH, Wang ZZ, Chen XX. A polydnavirus protein tyrosine phosphatase negatively regulates the host phenoloxidase pathway. Viruses. 2022 Dec 24;15(1):56. doi: 10.3390/v15010056.

共同作者发表的论文：

Zhu YT, Kuang SJ, Yao ZT, Sun YJ, Gao HS, Gao Q, Ding WB, He HL, Li YZ, Qiu L. Doublesex knockout via CRISPR/Cas9 disrupts fertility and sexual dimorphism of wings in the rice stem borer, Chilo suppressalis. Insect Biochem Mol Biol. 2025 Aug;182:104356. doi: 10.1016/j.ibmb.2025.104356.

Gong YW, Sun YJ, Kuang SJ, Ding WB, He HL, Gao Q, Gao HS, Li YZ, Qiu L. 20-Hydroxyecdysone regulates pupal fatty acid metabolism, maintaining lipid metabolic homeostasis in Chilo suppressalis. Insect Sci. 2025 Apr 18. doi: 10.1111/1744-7917.70053.

Hu JX, He QZ, Sun YJ, Ding WB, He HL, Gao HS, Gao Q, Qiu L, Li YZ. 20-hydroxyecdysone-mediated regulation of the ribosomal protein Cs40SRPS4 via CsE74A is essential for vitellogenesis in Chilo suppressalis. Insect Sci. 2025 Jun 12. doi: 10.1111/1744-7917.70092.

Wang YM, Gao Q, Shan L, Cao WY, Li YX, Ding WB, Gao HS, Xue J, He HL, Qiu L, Li YZ. A plant virus-derived siRNA modulates wing dimorphism and fertility of vector insects to enhance virus spread.J Adv Res.2026 Jan 25:S2090-1232(26)00087-1. doi: 10.1016/j.jare.2026.01.061.