于欢

一、个人简介

于欢，女，1987年7月生，湖北宜昌人。副教授，硕士研究生导师，招收农业昆虫与害虫防治专业学位硕士及资源利用与植物保护专业硕士。主要研究方向为昆虫病毒学及昆虫生理生化。

二、教育背景

2012/09–2015/12，西北农林科技大学，植物保护学院，农业昆虫与害虫防治专业，博研毕业，博士；

2009/09–2012/06，西北农林科技大学，植物保护学院，农业昆虫与害虫防治专业，研究生毕业，硕士；

2005/09–2009/06，西北农林科技大学，植物保护学院，植物保护专业，本科毕业，学士。

三、成果介绍

1.主持的主要科研项目；

l  国家自然科学基金面上项目，32070168，病毒对宿主细胞凋亡的显性负性调控机制，2021/01-2024/12，58万元，在研，主持。

l  国家自然科学基金青年项目，31700141，烟芽夜蛾囊泡病毒3h株对甜菜夜蛾脂肪体细胞的抗凋亡反应机制，2018/01-2020/12，24万元，结题，主持。

l  博士后基金特别资助项目，2018T110832，囊泡病毒编码的Caspase-like蛋白功能分析，2017/04-2018/10，15万元，结题，主持。

l  湖南省自然科学基金青年项目，2019JJ50234，改良型昆虫病毒杀虫剂的制备及其功能研究，2019/01-2021/12，5万元，结题，主持。

l  湖南农业大学引进人才科研启动项目，2019/01-2023/12，30万元，在研，主持。

2.主要论文成果；

1.        Huan Yu, Chang-Jin Yang, Yi-Yi Ou-Yang, Yue Tong, Hui-Yu Lan, Jia-Min Gan, Shi-Wei Li, Ding-Yi Bai, and Guo-Hua Huang. Enhanced virulence of genetically engineered Autographa californica nucleopolyhedrovirus owing to accelerated viral DNA replication aided by inserted ascovirus genes. Pesticide Biochemistry and Physiology, 2023, online, DOI: 10.1016/j.pestbp.2023.105382 (中科院大类I区, JCR Q1, IF=4.966)

2.        Huan Yu, Jin-Rong Li, Hua-Yan Xiao, Sheng-Kai Cao, Bin Chen, Ni Li, Gong Chen*, and Guo-Hua Huang*. Apoptosis or antiapoptosis? Interrupted regulated cell death of host cells by ascovirus infection in vitro. mBio, 2023, online, DOI: 10.1128/mbio.03119-22 (中科院大类I区, JCR Q1, IF=7.786)

3.        Huan Yu, Hua-Yan Xiao, Ni Li, Chang-Jin Yang, and Guo-Hua Huang*. An ascovirus utilizes different types of host larval regulated cell death mechanisms to produce and release vesicles. Journal of Virology, 2022, online, DOI: 10.1128/jvi.01566-22 (JCR Q1, IF=6.549)

4.        Chang-Jin Yang, Guang-Hao Ren, Xing-Xing Du, Shi-Wei Li, Yu-Rui Qian, Guo-Hua Huang*, and Huan Yu*. Comparisons of pathogenic course of two Heliothis virecens ascovirus isolates (HvAV-3i and HvAV-3j) in four noctuid (Lepidoptera) pest species. Journal of Invertebrate Pathology, 2022, 107734. (JCR Q1, IF=2.795)

5.        Huan Yu, Yi-Yi Ou-Yang, Chang-Jin Yang, Ni Li, Madoka Nakai* and Guo-Hua Huang*. 3H-31, a non-structural protein of Heliothis virescens ascovirus 3h, inhibits the host larval cathespin and chitinase activities. Virologica Sinica, 2021, 36; 1036-1051. (JCR Q2, IF=6.947)

6.        Huan Yu, Chang-Jin Yang, Ni Li, Ying Zhao, Zhuang-Mei Chen, Si-Jia Yi, Zi-Qi Li, Michael J. Adang* and Guo-Hua Huang*. Novel strategies for the biocontrol of noctuid pests (Lepidoptera) based on improving ascovirus infectivity using Bacillus thuringiensis. Insect Science, 2021, 28: 1452-1467. (中科院大类I区, JCR Q1, IF=3.605)

7.        Huan Yu, Zi-Qi Li, Yi-Yi Ou-Yang and Guo-Hua Huang*. Identification of four caspase genes from Spodoptera exigua (Lepidoptera: Noctuidae) and their regulations toward different apoptotic stimulations. Insect Science, 2020, 27: 1158-1172. (中科院大类I区, JCR Q1, IF=3.605)

8.        Huan Yu, Lei He, Zi-Qi Li, Ni Li, Yi-Yi Ou-Yang and Guo-Hua Huang*. Altering of host larval (Spodoptera exigua) calcineurin activity in response to ascovirus infection. Pest Management Science, 2020, 76: 1048-1059. (中科院大类I区, JCR Q1, IF=4.462)

9.        Huan Yu, Yi-Yi Ou-Yang, Ni Li, Madoka Nakai* and Guo-Hua Huang*. In vitro infectious risk assessment of Heliothis virescens ascovirus 3j (HvAV-3j) toward non-target vertebrate cells. Virologica Sinica. 2019, 34: 423-433. (JCR Q2, IF=6.947)

10.    Huan Yu, Zi-Qi Li, Lei He, Yi-Yi Ou-Yang, Ni Li, and Guo-Hua Huang*. Response analysis of host Spodoptera exigua larvae to infection by Heliothis virescens ascovirus 3h (HvAV-3h) via transcriptome. Scientific Reports. 2018, 8: 5367. (JCR Q1, IF=4.996)

11.    Huan Yu, Lei He, Yi-Yi Ou-Yang and Guo-Hua Huang*. Preparation and molecular characterization of a polyclonal antibody as an efficient cutworm reference protein. Journal of Asia-Pacific Entomology. 2018, 21: 786-792. (JCR Q2, IF=1.562)

12.    Huan Yu, Bin Zhou, Jiao Meng, Jian Xu, Tong-xian Liu* and Dun Wang*. Recombinant Helicoverpa armigera nucleopolyhedrovirus with arthropod-specific neurotoxin gene RjAa17f from Rhopalurus junceus enhances the virulence against the host larvae. Insect Science. 2017, 24: 397-408. (中科院大类I区, JCR Q1, IF=3.605)

13.    Huan Yu, Tong-Xian Liu* and Dun Wang*, Genomic characterization and phylogenetic analysis of Chinese sacbrood virus isolated from Loess Plateau, China. Genetics and Molecular Research. 2016, 15(3). DOI: 10.4238/gmr.15036928. (JCR Q4)

14.    Huan Yu, Jian Xu, Qiang Liu, Tong-Xian Liu* and Dun Wang*. Ha83, a Chitin Binding Domain Encoding Gene, Is Important to Helicoverpa armigera Nucleopolyhedrovirus Budded Virus Production and Occlusion Body Assembling. Scientific Reports. 2015, 5: 11088. (JCR Q1, IF=4.996)

15.    Huan Yu, Jiao Meng, Jian Xu, Tong-xian Liu* and Dun Wang*. A Novel Neurotoxin Gene ar1b Recombination Enhances the Efficiency of Helicoverpa armigera Nucleopolyhedrovirus as a Pesticide by Inhibiting the Host Larvae Ability to Feed and Grow. PloS One. 2015, 10(8): e0135279. (JCR Q1, IF=3.752)

16.    李诗薇, 欧阳依依, 杨长锦, 童悦, 甘佳敏, 黄国华, 于欢*. 烟芽夜蛾囊泡病毒3h株编码的3H-117蛋白能干扰AcMNPV的口服活性. 微生物学报, 2022, 62: 131-144.

17.    宋晓慧, 杨长锦, 黎妮, 黄国华*, 于欢*. 甜菜夜蛾半胱天冬酶基因的克隆及对细胞凋亡诱导剂和病原微生物感染的表达响应. 昆虫学报, 2021, 64: 800-808.

18.    曹生凯, 何磊, 黎妮, 王星*, 于欢*. 烟芽夜蛾囊泡病毒3h株3h-38基因原核表达及转录、表达时相分析. 环境昆虫学报, 2021, 43: 1113-1121.

19.    于欢, 吕婷婷, 李晓峰, 王敦*. HearNPV侵染对棉铃虫中肠碱性磷酸酶活性及表达水平的影响. 西北农林科技大学学报（自然科学版）, 2012, 40: 127-130.

20.    Ge-Ge Yuan, Lin-Chao Zhao, Yuan-Wen Du, Huan Yu, Xiao-Bin Shi, Wen-Chao Chen, and Gong Chen*. Repellence or attraction: secondary metabolites in pepper mediate attraction and defense against Spodoptera litura. Pest Management Science, 2022, 72: 4859-4870. (中科院大类I区, JCR Q1, IF=4.462)

21.    Lei He^#, Huan Yu^#, Cun-Yi Xu, Ying Zhao, Fu-Xiang Yang, Ya-Dong Guo, Guo-Hua Huang*. Molecular characterization, activity analysis and transcriptional detection of chitinases encoded in the genome of Spodoptera exigua. Journal of Asia-Pacific Entomology. 2019, 22: 499-505. (JCR Q2, IF=1.562)

22.    Zi-Qi Li, Huan Yu and Guo-Hua Huang*. Changes in lipid, protein and carbohydrate metabolism in Spodoptera exigua larvae associated with infection by Heliothis virescens ascovirus 3h. Journal of Invertebrate Pathology. 2018, 155: 55-63. (JCR Q1, IF=2.795)

23.    Jiang-Bin Fan, Sabrina van de Velde, Wen-Bo Sun, Huan Yu, Ya-lin Zhang, and Dun Wang. Enhanced toxicity of Cry2Ab with cantharidin and its analogues on Mythimna separate. Journal of Applied Entomology. 2017, 141: 363-371. (JCR Q1, IF=2.183)

24.    Zheng-Wei Wu, Jiang-Bin Fan, Huan Yu, Ya-Lin Zhang and Dun Wang. Ultraviolet protection of the Cydia pomonella granulovirus using zinc oxide and titanium dioxide. Biocontrol Science and Technology. 2015, 25: 97-107. (JCR Q2, IF=1.810)

25.    Xiao-Feng Li, Huan Yu, Chuan-Xi Zhang, Hui Chen and Dun Wang. Helicoverpa armigera nucleopolyhedrovirus orf81 is a late gene involved in budded virus production. Archives of Virology. 2014, 159: 2011-2022. (JCR Q3, IF=2.685)

26.    黄诗迪, 黄彩萍, 于欢, 王敦*. 棉铃虫核型多角体病毒感染对宿主昆虫GST活性及其表达水平的影响. 西北农林科技大学学报（自然科学版）, 2015, 43: 5.

27.    刘新宇, 于欢, 高宝国, 张彦明*, 王敦*. 梯度条带PCR快速检测CSBV方法的建立[J]. 动物医学进展, 2012, 33: 4.

28.    曹军, 于欢, 张瑞凤, 王沛, 张雅林, 王敦*. 僵蚕提取物对棉铃虫的胃毒作用和碱性磷酸酶活性的影响. 西北林学院学报, 2012, 27: 4.

29.    陈东旭, 于欢, 徐红星, 张雅林, 王敦*. 小菜蛾性信息素结合蛋白Ⅰ基因的表达及多克隆抗体制备. 西北农业学报, 2011, 20: 182-186.

30.    甘恩宇, 李晓峰, 于欢, 吴正伟, 徐利, 张雅林, 王敦*. 3株苹果蠹蛾颗粒体病毒本土株的毒力测定与田间防效. 西北农林科技大学学报（自然科学版）, 2011, 39: 119-122.