于欢

一、个人简介

于欢，女，1987年7月生，湖北宜昌人。副教授，博士、硕士研究生导师，招收农业昆虫与害虫防治专业学位博士、学位硕士及资源利用与植物保护专业硕士。主要研究方向为昆虫病理学。

二、教育背景

2012/09–2015/12，西北农林科技大学，植物保护学院，农业昆虫与害虫防治专业，博研毕业，博士；

2009/09–2012/06，西北农林科技大学，植物保护学院，农业昆虫与害虫防治专业，研究生毕业，硕士；

2005/09–2009/06，西北农林科技大学，植物保护学院，植物保护专业，本科毕业，学士。

三、成果介绍

1.主持的主要科研项目；

l 芙蓉计划科技创新青年人才，2025RC3175，湖南省创新平台与人才计划，30.0万元，在研，主持。

l 《基于快速提高细胞通透性的高效病毒蛋白-细菌杀虫剂的创制》，YLS-2025-ZY04066，岳麓山实验室项目-自由探索项目-青年项目，20.0万元，在研，主持。

l 《囊泡病毒操纵宿主细胞不同类型调控性细胞死亡的分子机制》，湖南省自然科学基金面上项目，5.0万元，在研，主持。

l 《病毒对宿主细胞凋亡的显性负性调控机制》，32070168，国家自然科学基金面上项目，58.0万元，结题，主持。

l 《烟芽夜蛾囊泡病毒3h株对甜菜夜蛾脂肪体细胞的抗凋亡反应机制》，31700141，国家自然科学基金青年项目，24.0万元，结题，主持。

l 《囊泡病毒编码的Caspase-like蛋白功能分析》，2018T110832，中国博士后科学基金特别资助，15.0万元，结题，主持。

l 《改良型昆虫病毒杀虫剂的制备及其功能研究》，2019JJ50234，湖南省自然科学基金青年项目，5.0万元，结题，主持。

l 湖南农业大学神农英才II等人才科研启动项目，30.0万元，结题，主持。

l 《棉田恶性病虫草害绿色高效防控技术研究与示范》，2023NK2015，湖南省重点研发计划，80.0万元，在研，参与。

2.主要论文成果；

2026年

1. Zheng Zhai, Shi-Hao Hu, Bei-Long Chen, Xin-Yu Xiao, Xi-Hui Cao, Zi-Yao Liu, and Huan Yu*. Hyperlipidemia of Spodoptera exigua larvae caused by the infection of Heliothis virescens ascovirus 3h contributes to the viral DNA replication and virions’ storage. Pesticide Biochemistry and Physiology, 2026, 218: 106908.

2. Zi-Yao Liu, Heba A. H. Zaghloul, Jin-Rong Li, Zheng Zhai, Yu Wang, Le Zhou, Jia-Hui Li, Yu-Ting Shi, Yu Guo, Dan-Hong Wang, Lin Chen, Jiang-Bin Fan, Huan Yu*, and Yong-Sheng Zhang*. Insecticidal applications of insect gut-derived Serratia sp. As biocontrol agent against six Lepidoptera species. Entomologia Generalis, 2025, DOI: 10.1127/entomologia/3219.

2025年

3. Le Zhou, Yu Wang, Zi-Yao Liu, Xiang Liu, Zheng Zhai, Sheng-Kai Cao, Qi-Qiang Zhao, Heba A.H. Zaghloul, Xiao-Bin Shi, Huan Yu*, Hao Su, and Yong-Sheng Zhang*. Biological activity and field efficacy of Bacillus thuringiensis kurstati strains with protein film adjuvants (PFAs) against Plutella xylostella (Lepidoptera: Plutellidae). Pest Management Science, 2025, 81: 41084120.

4. Yu Wang, Zhou Yu, Bei-Long Chen, Shao-Shao He, Zi-Yao Liu, Zheng Zhai, Lin Chen, Jiang-Bin Fan, Huan Yu*, Zhi-Ping Zuo*, and Yong-Sheng Zhang*. Pepper feeding derivative Brucella sp. in the gut of Spodoptera litura (Lepidoptera: Noctuidae) affect the growth and development of host larvae. Pesticide Biochemistry and Physiology, 2025, 209: 106332. (中科院大类I区)

5. 郭鹬, 任广豪, 刘金源, 钟子雯, 于欢*. 一株对草地贪夜蛾具有胃毒活性的克雷伯氏菌的分离及全基因组分析. 环境昆虫学报, 2025, online.

2024年

6. Yu-Ting Shi, Zheng Zhai, Zi-Yao Liu, Le Zhou, Hua Yang, Lin Chen, Yong-Sheng Zhang, and Huan Yu*. Expressional response of hsp70 genes against abiotic and entomopathgenic stresses in four different noctuid larval species (Lepidoptera: Noctidae). Pesticide Biochemistry and Physiology, 2024, 204: 106059. (中科院大类I区, IF_{5 years}=4.7)

2023年

7. Huan Yu, Hong Chen, Ni Li, Chang-Jin Yang, Hua-Yan Xiao, Gong Chen*, and Guo-Hua Huang*. Flexible changes to the Heliothis virescens ascovirus 3h (HvAV-3h) virion components affects pathogenicity against different host larvae species. Microbiology Spectrum, 2023, e0248823. (中科院大类I区, IF_{5 years}=5.9)

8. Xing-Xing Du, Sheng-Kai Cao, Hua-Yan Xiao, Chang-Jin Yang, Ai-Ping Zeng, Gong Chen, and Huan Yu*. Feeding Spodoptera exigua (Lepidoptera: Noctuidae) larvae with Escherichia sp. (SePC-12) increases larval juvenile hormone levels inhibiting cannibalism. Communications Biology, 2023, 6: 1086. (中科院大类II区, IF_{5 years}=6.3)

9. Sheng-Kai Cao, Xing-Xing Du, Gong Chen, Ai-Ping Zeng, and Huan Yu*. Relative activity of 15 bacterial strains against the larvae of Helicoverpa armigera, Spodoptera exigua and Spodoptera litura (Lepidoptera: Noctuidae). Journal of Economic Entomology, 2023, 116(5): 1505-1517. (中科院大类II区, IF_{5 years}=2.3)

10. Huan Yu, Chang-Jin Yang, Yi-Yi Ou-Yang, Yue Tong, Hui-Yu Lan, Jia-Min Gan, Shi-Wei Li, Ding-Yi Bai, and Guo-Hua Huang*. Enhanced virulence of genetically engineered Autographa californica nucleopolyhedrovirus owing to accelerated viral DNA replication aided by inserted ascovirus genes. Pesticide Biochemistry and Physiology, 2023, 192: 105382 (中科院大类I区, IF_{5 years}=4.7)

11. Huan Yu, Jin-Rong Li, Hua-Yan Xiao, Sheng-Kai Cao, Bin Chen, Ni Li, Gong Chen*, and Guo-Hua Huang*. Apoptosis or antiapoptosis? Interrupted regulated cell death of host cells by ascovirus infection in vitro. mBio, 2023, online, 14(1): e0311922 (中科院大类I区, IF_{5 years}=6.9)

12. Huan Yu, Hua-Yan Xiao, Ni Li, Chang-Jin Yang, and Guo-Hua Huang*. An ascovirus utilizes different types of host larval regulated cell death mechanisms to produce and release vesicles. Journal of Virology, 2023, 97(1): e0156622 (中科院大类II区, IF_{5 years}=4.9)

13. Lang Ming^#, Yuan-Wen Du^#, Ge-Ge Yuan, Qi Su, Xiao-Bin Shi, Huan Yu*, and Gong Chen*. Spodoptera litura larvae are attracted by HvAV-3h-infected S. litura larvae-damaged pepper leaves. Pest Management Science, 2023. doi: 10.1002/ps.7449. (中科院大类I区, IF_{5 years}=4.4)

14. 贺韶韶, 余宙, 石瑞琪, 庄浩楠, 陈功, 于欢*. 抗虫辣椒叶片对斜纹夜蛾幼虫相关生理生化指标的影响. 环境昆虫学报, 2024, 46(3): 650-658.

15. 余宙, 贺韶韶, 庄浩楠, 袁格格, 陈功, 于欢*. 抗虫辣椒‘BLTY’品系对斜纹夜蛾肠道细菌多样性的影响. 福建农林大学学报（自然科学版）, 2024, 53(2): 181-190.

2022年

16. Chang-Jin Yang, Guang-Hao Ren, Xing-Xing Du, Shi-Wei Li, Yu-Rui Qian, Guo-Hua Huang*, and Huan Yu*. Comparisons of pathogenic course of two Heliothis virecens ascovirus isolates (HvAV-3i and HvAV-3j) in four noctuid (Lepidoptera) pest species. Journal of Invertebrate Pathology, 2022, 107734. (中科院大类III区, IF_{5 years}=3.1)

17. Ge-Ge Yuan, Lin-Chao Zhao, Yuan-Wen Du, Huan Yu, Xiao-Bin Shi, Wen-Chao Chen, and Gong Chen*. Repellence or attraction: secondary metabolites in pepper mediate attraction and defense against Spodoptera litura. Pest Management Science, 2022, 72: 4859-4870. (中科院大类I区, IF_{5 years}=4.4)

18. Long Liu, Huan Yu, and Dun Wang*. Genomic and biological characteristics of an alphabaculovirus isolated from Trabala vishnou gigantina. Virus Research, 2022, 308: 198630. (中科院大类III区, IF_{5 years}=4.0)

2021年

19. Huan Yu, Yi-Yi Ou-Yang, Chang-Jin Yang, Ni Li, Madoka Nakai* and Guo-Hua Huang*. 3H-31, a non-structural protein of Heliothis virescens ascovirus 3h, inhibits the host larval cathespin and chitinase activities. Virologica Sinica, 2021, 36; 1036-1051. (中科院大类II区, IF_{5 years}=4.9)

20. Huan Yu, Chang-Jin Yang, Ni Li, Ying Zhao, Zhuang-Mei Chen, Si-Jia Yi, Zi-Qi Li, Michael J. Adang* and Guo-Hua Huang*. Novel strategies for the biocontrol of noctuid pests (Lepidoptera) based on improving ascovirus infectivity using Bacillus thuringiensis. Insect Science, 2021, 28: 1452-1467. (中科院大类I区, IF_{5 years}=3.6)

21. 李诗薇, 欧阳依依, 杨长锦, 童悦, 甘佳敏, 黄国华, 于欢*. 烟芽夜蛾囊泡病毒3h株编码的3H-117蛋白能干扰AcMNPV的口服活性. 微生物学报, 2021, 62: 131-144.

22. 宋晓慧, 杨长锦, 黎妮, 黄国华*, 于欢*. 甜菜夜蛾半胱天冬酶基因的克隆及对细胞凋亡诱导剂和病原微生物感染的表达响应. 昆虫学报, 2021, 64: 800-808.

23. 曹生凯, 何磊, 黎妮, 王星*, 于欢*. 烟芽夜蛾囊泡病毒3h株3h-38基因原核表达及转录、表达时相分析. 环境昆虫学报, 2021, 43: 1113-1121.

2020年

24. Huan Yu, Zi-Qi Li, Yi-Yi Ou-Yang and Guo-Hua Huang*. Identification of four caspase genes from Spodoptera exigua (Lepidoptera: Noctuidae) and their regulations toward different apoptotic stimulations. Insect Science, 2020, 27: 1158-1172. (中科院大类I区, IF_{5 years}=3.6)

25. Huan Yu, Lei He, Zi-Qi Li, Ni Li, Yi-Yi Ou-Yang and Guo-Hua Huang*. Altering of host larval (Spodoptera exigua) calcineurin activity in response to ascovirus infection. Pest Management Science, 2020, 76: 1048-1059. (中科院大类I区, IF_{5 years}=4.4)

2019年

26. Huan Yu, Yi-Yi Ou-Yang, Ni Li, Madoka Nakai* and Guo-Hua Huang*. In vitro infectious risk assessment of Heliothis virescens ascovirus 3j (HvAV-3j) toward non-target vertebrate cells. Virologica Sinica. 2019, 34: 423-433. (中科院大类II区, IF_{5 years}=4.9)

27. Ying Zhao, Huan Yu, Lei He, Ni Li, Guo-Hua Huang*. 3H-117, a structural protein of Heliothis virescens ascovirus 3h (HvAV-3h). Virus Genes. 2019, 55: 688-695. (中科院大类IV区, IF_{5 years}=2.0)

28. Lei He^#, Huan Yu^#, Cun-Yi Xu, Ying Zhao, Fu-Xiang Yang, Ya-Dong Guo, Guo-Hua Huang*. Molecular characterization, activity analysis and transcriptional detection of chitinases encoded in the genome of Spodoptera exigua. Journal of Asia-Pacific Entomology. 2019, 22: 499-505. (中科院大类III区, IF_{5 years}=1.5)